Sequences and topology.

European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK e-mail: [email protected] Introduction In what follows, we give an overview of the eight reviews in the Sequences and topology section, describing and summarizing their content. Basically, the reviews this year follow the overall progression in bioinformatics from genome sequence to functional genomics analysis to protein structure. We start with reviews by Karlin and Lancet on genome analysis, the former focusing on more global issues and the latter on what can be learned from specific families. Then, the review by Orengo discusses mapping from the genome to protein families and structure. Stolovitzky talks about analyzing expression information, functional genomics data that characterize the sequence products. The next group of reviews, by Eisenberg and Janin, discuss protein–protein interactions, the interactome, and the current excitement in interpreting this. Finally, we have reviews by Jackson and Westhead, and Nakamura on more detailed aspects of three-dimensional site analysis.